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Request for DNA
samples of dogs affected with Hereditary Cataracts and that of
their close relatives
As you are no doubt aware,
Alaskan Malamutes are pre-disposed to Hereditary Cataracts. At
the present time very little information exists on the mode of
inheritance and the gene involved. I am undertaking a voluntary
scheme where by I collect DNA samples of dogs affected with
Hereditary Cataracts (HC) and that of their close relatives and
send the samples to the Animal Health Trust to assist in their
research. I am appealing to everyone who would like to see the
gene responsible for HC in Malamutes identified to help us in
this project.
The Animal Health Trust (AHT)
work towards understanding the genetics of inherited conditions
and aim to develop DNA based diagnostic tests which breeders can
then use to help minimise and potentially eradicate the
occurrence of certain genetic defects.
The AHT’s progress in
identifying marker genes for HC:
Over a 6 year period, the AHT
collected samples and undertook research which enabled them to
identify a mutation in one gene which they found was responsible
for HC in Staffordshire Bull Terriers.
The AHT then examined DNA from
other breeds that suffered from HC and found that Boston
Terriers whom were affected with HC carried two copies of the
same gene mutation as SBT’s. This information enabled the AHT to
create a DNA test for SBT’s and Boston’s.
DNA samples from a few
Australian Shepherd Dogs were examined and it was discovered
that even though they had a different mutation to SBT's and
Boston's, it was in the same gene. Therefore the AHT believe
that they have identified the gene that causes HC in Aussies and
are finalising the identification of the marker gene and its
inheritance pattern in the Australian Shepherd, with the view to
making a DNA test available in the near future.
Whilst performing this
research, it was found that Golden Retrievers and American
Cocker Spaniels affected with HC did not carry this particular
mutation, so the AHT are currently researching which gene may be
involved in these cases. The AHT are also undertaking research
into the gene responsible for HC in the Siberian Husky.
In order to identify whether or
not a breed carries a similar mutation to those already
discovered, The Animal Health Trust (AHT) require DNA samples
from affected individuals and that of close relatives. I am
organising samples to be sent and kept on file to be used in
their ongoing research.
All I will need from owners is
a copy of the individuals 5 generation pedigree and a copy of
their last eye test certificate. I will provide the kits
required to take the samples, which, along with the paperwork,
will then be passed on to the AHT. The process is very simple, a
cheek swab is all that is needed to collect the DNA sample from
the inside of the dog’s mouth. It is important to note that the
AHT should be informed of any significant health changes that
occur after the sample has been submitted.
The more samples the AHT
receive, the more likely they are to be able to locate the gene
concerned and to establish the mode of inheritance of HC in the
Alaskan Malamute in the future.
If you would like to contribute
a DNA sample for ongoing research (overseas samples will also be
gratefully accepted) please contact:
koyukuk_sleddogs@yahoo.co.uk
All help in this matter will be
very much appreciated
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